TABLE 1.

Grouping and time of medication.

Groups\Time(days)	Day 0	Day 1∼3	Day 4∼7
C group	PBS injection	Sterile water + PBS injection	Sterile water + PBS injection
D group	PBS injection	DSS solution + PBS injection	DSS solution + PBS injection
MD group	PBS injection	DSS solution + PBS injection	DSS solution + metfromin injection
P group	Metformin injection	DSS solution + metformin injection	DSS solution + metformin injection
M group	PBS injection	Sterile water + metformin injection	Sterile water + metformin injection

Note: C = Control, D = DSS group, MD = DSS + Metformin, P = DSS + pre-Metformin, M = Metformin.