Table 2:
Univariable Poisson regression CAA vwMRI findings and AIS
| Stroke Predictor | Stroke (−) (n = 15) | Stroke (+) (n = 35) | Univariable PR (95% CI) | P Value |
|---|---|---|---|---|
| VWE, n (%) | 5 (33.3) | 24 (68.6) | 1.6 (1.0–2.5) | .044 |
| Maximum percent stenosis, mean (SD) | 10.3 (20.7) | 16.9 (20.8) | 1.6 (0.7–3.6) | .297 |
| Age, mean (SD) | 69.4 (8.5) | 73.0 (7.2) | 1.01 (0.99−1.05) | .146 |
| Female, n (%) | 7 (46.7) | 20 (57.1) | 1.1 (0.8–1.7) | .507 |
| Hypertension, n (%) | 13 (86.7) | 30 (85.7) | 1.0 (0.6–1.6) | .928 |
| Hyperlipidemia, n (%) | 10 (66.7) | 22 (62.9) | 1.0 (0.7–1.4) | .796 |
| Diabetes, n (%) | 2 (13.3) | 12 (34.3) | 1.3 (1.0–1.9) | .080 |
| Smoking, n (%) | 9 (60.0) | 11 (31.4) | 0.7 (0.4–1.1) | .095 |
| Antiplatelet, n (%) | 5 (33.3) | 13 (37.1) | 1.1 (0.7–1.5) | .796 |
| Anticoagulation, n (%) | 1 (6.7) | 4 (11.4) | 1.2 (0.7–1.9) | .546 |
| Antihypertension, n (%) | 12 (80.0) | 25 (71.4) | 0.9 (0.6–1.3) | .499 |
| Statin, n (%) | 8 (53.3) | 19 (54.3) | 1.0 (0.7–1.5) | .951 |
| Time between symptom onset and MR imaging in days, mean (SD) | 5.5 (2.4) | 3.2 (2.3) | 0.9 (0.8–1.0) | .006 |
| Inflammatory marker elevation, n (%), n = 30 available | 1 (16.7) n = 6 | 9 (37.5) n = 24 | 1.2 (0.9–1.7) | .282 |
Note:—Univariable Poisson regression was initially performed with PR values, with 95% CI and P values above. All potential confounding variables with P < .20 from the univariable analysis were placed in an initial multivariable Poisson regression model for AIS; then variables were eliminated in a backward fashion to the threshold P < .20. Four factors remained in the final multivariable regression model for AIS: VWE (PR = 1.5; 95% CI, 1.1–2.2; P = .022), age (PR = 1.02; 95% CI, 1.0–1.05; P = .036), time between symptoms and MR imaging (PR = 0.9; 95% CI, 0.8–0.9; P < .001), and smoking (PR = 0.7; 95% CI, 0.5–1.0; P = .042)