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. 2021 May 17;49(10):5956–5966. doi: 10.1093/nar/gkab370

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Crystal structure of the SARS-CoV-2 NSP7-NSP8 complex. (A, B) Orthogonal views of the SARS-CoV-2 NSP7-NSP8 complex, with the intermolecular interactions at the two oligomer interfaces shown in expanded views. The interacting residues are shown in stick representation. The hydrogen bond is shown as a red dashed line. The side chains of NSP7 K2 and Q19, which are untraceable in the crystal structure, are marked by asterisks. (C, D) Color-coded sequence conservation of SARS-CoV-2 NSP8 (C) and NSP7 (D), analyzed using the ConSurf server (https://consurf.tau.ac.il/) (33).