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. 2021 May 17;49(10):5956–5966. doi: 10.1093/nar/gkab370

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Structural analysis of the dynamic assembly of the NSP7-NSP8 complex. (A) Structural overlay of the SARS-CoV-2 NSP7-NSP8 tetrameric complex with the tetramer I of the SARS-CoV NSP7-NSP8 tetrameric complex (PDB 2AHM). (B) Structural overlay of the SARS-CoV-2 NSP7–NSP8 tetrameric complex with the SARS-CoV-2 NSP7–NSP8 dimer in the RNA-bound state of SARS-CoV-2 RdRP (PDB 6YYT). For clarity, NSP12 and the RNA molecule are omitted. (C) Structural overlay of the SARS-CoV-2 NSP7-NSP8 tetrameric complex with the SARS-CoV-2 NSP7–NSP8 dimer in the RNA-free state of SARS-CoV-2 RdRP (PDB 6M71). (D) Structural overlay of the SARS-CoV-2 NSP7–NSP8 tetrameric complex with the FCoV NSP7–NSP8 dimer in the RNA-free state of FCoV RdRP (PDB 3UB0). (E) Close-up view of the intermolecular interactions at the interface II of the FCoV NSP7-NSP8 complex. (F) Expanded view of the interface II showing NSP7 and NSP8 residues that are divergent between SARS-COV-2 and FCoV in stick representation.