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. 2021 May 17;49(10):5956–5966. doi: 10.1093/nar/gkab370

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — A model for the dynamic assembly of the NSP7–NSP8 complex. The mixed populations of NSP7 monomer, NSP8 monomer, NSP8 dimer, NSP7–NSP8 heterodimer, and NSP7–NSP8 heterotetramer co-exist in solution. The population of NSP7–NSP8 heterodimer is transient due to coupled intermolecular interactions between interface I and interface II. In the presence of NSP12 and RNA, NSP7–NSP8 heterodimer and NSP8 monomer associate with NSP12 to form a functional RdRP complex.