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. 2021 May 8;49(10):5891–5904. doi: 10.1093/nar/gkab307

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Regulatory scheme of the Vibrio vulnificus add adenine riboswitch. (A) Secondary structure model of the ON and OFF conformers of the adenine riboswitch. In the absence of adenine, the riboswitch allows the formation of a stem-loop sequestering the ribosome access to the Shine-Dalgarno (GAA) and AUG initiation codon (boxed), thus preventing the initiation of translation. However, upon adenine (Ade) binding, the riboswitch folds into an alternative structure in which the Shine-Dalgarno and the AUG initiation codon are accessible to allow translation initiation. (B) Secondary structure model of the add adenine aptamer. The sequence and secondary structure are shown with P1, P2 and P3 helical domains. Dotted lines represent Watson–Crick base pairing interactions occurring within the aptamer core region. The bound adenine is shown in a black circle. The numbering is based from a previous study (66).