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. 2021 Jun 10;16(6):e0252714. doi: 10.1371/journal.pone.0252714

Table 2. Results of the clinical and analytical variables.

Clinical variables BPE MPE
Gender (male/female) a 138/60 (69.7/30.3) 59/50 (54.1/45.9)
Age (years)b 65.5 (51–77.25) 70 (60–80.5)
Previous cancera 35 (17.7) 34 (31.2)
Smoker a 106 (53.5) 57 (52.3)
Dyspnoea a 123 (62.1) 89 (81.7)
Chest pain a 97 (49) 39 (35.8)
Cough a 79 (30.9) 35 (32.1)
Constitutional syndrome a 28 (14.1) 46 (42.2)
Haemoptysis a 7 (3.5) 5 (4.6)
Fever a 72 (36.4) 8 (7.3)
Massive effusion a, c 17 (8.6) 30 (27.5)
Analytical variables b BPE MPE
LDH (U/L) 438 (283–998) 522 (341–832)
Protein (g/dL) 4.59 (3.9–5.03) 4.4 (3.78–4.87)
pH 7.39 (7.29–7.44) 7.40 (7.32–7.45)
ADA (U/L) 24 (19.4–40.62) 20 (14.8–25.85)
Glucose (mg/dL) 99.5 (76–127) 105 (90–126)
Polymorphonuclear leukocytes (%) 21 (5–59) 9 (2–20)
Mononuclear leukocytes (%) 70 (31.25–90) 82 (50.5–94.25)

BPE = benign pleural effusion; MPE = malignant pleural effusion; constitutional syndrome includes at least one of the following variables: asthenia, anorexia, and/or weight loss; LDH = lactate dehydrogenase; ADA = adenosine deaminase.

a Data are presented as frequencies and percentages

b Data are presented as medians and interquartile ranges (IQRs)

c Radiological effusion features: pleural effusion causing opacification of an entire hemithorax or when the fluid reaches the aortic arch.