Fig 5. Pre-CHMI antibody comparisons between vaccination and placebo groups.
(A) Antibodies to PfCSP (net OD 1.0) prior to CHMI. Filled circles are uninfected (protected) subjects and open circles are infected subjects. (B) Antibodies to PfSPZ (net aIFA200K) measure prior to CHMI. The y-axis refers to aIFA fluorescence intensity of 2x105. Filled circles are uninfected (protected) subjects and open circles are infected subjects. (C) Net reciprocal serum dilution for 80% inhibition of PfSPZ invasion of hepatocytes (HC-04 cells) prior to CHMI. Filled circles are uninfected (protected) subjects and open circles are infected subjects. Horizontal lines represent medians and bars are interquartile ranges for all panels. p values for Wilcoxon-Mann-Whitney tests are shown in A-B.