Table 3. Miltefosine treatment outcomes.

Day 28
	Overall N = 66a,b		Boru Meda N = 50		Gondar N = 16
Outcome	n (%)	95% CI	n (%)	95% CI	n (%)	95% CI
Cure	12 (13.6)		12 (24.0)	14.0–37.9	0 (0)	0–22.3
Good improvement	46 (66.0)	2.2–38.5	35 (70.0)	60.0–83.9	11 (68.8)	50.0–91.0
Partial improvement	8 (20.4)	17.6–95.9	3 (6.0)	0–19.9	5 (31.2)	12.5–53.5
No improvement	0 (0)		0 (0)	0–13.9	0 (0)	0–2.3
Day 90
	Overall N = 60a		Boru Meda N = 44		Gondar N = 16
	n (%)	95% CI	n (%)	95% CI	n (%)	95% CI
Cure	34 (35.7)	13.1–62.1	34 (72.7)	61.4–85.9	2 (12.5)	0–40.8
Good improvement	17 (40.9)	10.9–78.0	8 (20.5)	9.1–33.6	8 (50.0)	31.3–78.3
Partial improvement	0	-	0 (0)	0–13.2	0 (0)	0–28.3
No improvement	0	-	0 (0)	0–13.2	0 (0)	0–28.3
Relapse	9 (23.4)	3.3–60.2	3 (6.8)	0–20.0	6 (37.5)	18.8–65.8
Day 180
	Overall N = 63a		Boru Meda N = 48		Gondar N = 15
	n (%)	95% CI	n (%)	95% CI	n (%)	95% CI
Cure	39 (48.7)	25.2–72.6	35 (72.9)	62.5–85.8	4 (26.7)	6.7–52.7
Good improvement	9 (19.0)	3.1–54.1	7 (14.6)	4.2–27.5	2 (13.3)	0–39.4
Partial improvement	0	-	0 (0)	0–12.9	0 (0)	0–26.1
No improvement	0	-	0 (0)	0–12.9	0 (0)	0–26.1
Relapse	15 (32.3)	11.8–61.0	6 (12.5)	2.0–25.4	9 (60.0)	40.0–86.1

CI: Confidence interval. This table shows the per protocol analysis.

^aProportions and 95% confidence intervals shown here are adjusted by site.

^bAdjusted proportions and confidence intervals were calculated for day 28 by adding one cured, one good improvement and one partial improvement dummy patient to Gondar to obtain estimates which could otherwise not be obtained due to sparse data.