Table 4. Multivariate model by logistic regression of factors associated with long-term use of PPIs (>3 years).
| Characteristics | Univariate analysis | Multivariate analysis | ||||||
|---|---|---|---|---|---|---|---|---|
| OR | IC95% | p | OR | IC95% | p | |||
| Age in Years | 1.034 | 1.020 | 1.048 | <0.001 | 1.032 | 1.017 | 1.046 | <0.001 |
| Female | 0.931 | 0.596 | 1.453 | 0.752 | - | - | - | - |
| Smoker | 1.171 | 0.468 | 2.926 | 0.736 | - | - | - | - |
| Alcohol use | 1.388 | 0.752 | 2.563 | 0.294 | - | - | - | - |
| BMI | 1.073 | 1.024 | 1.125 | 0.003 | 1.070 | 1.017 | 1.124 | 0.008 |
| No other health problems | 0.478 | 0.292 | 0.781 | 0.003 | - | - | - | - |
| Heart problems | 2.001 | 1.289 | 3.107 | 0.002 | - | - | - | - |
| Bone problems | 1.037 | 0.421 | 2.554 | 0.937 | - | - | - | - |
| Do not use other medicines | 0.429 | 0.256 | 0.718 | 0.001 | - | - | - | - |
| ATC class | ||||||||
| Angiotensin II receptor blockers | 1.286 | 0.780 | 2.119 | 0.324 | - | - | - | - |
| HMG CoA reductase inhibitors | 2.735 | 1.642 | 4.552 | 0.000 | - | - | - | - |
| Biguanides | 1.439 | 0.778 | 2.662 | 0.246 | - | - | - | - |
| Thiazides | 1.040 | 0.538 | 2.011 | 0.908 | - | - | - | - |
| Multivitamins with minerals | 1.872 | 0.973 | 3.602 | 0.060 | - | - | - | - |
| Beta blocking agents | 1.204 | 0.588 | 2.469 | 0.611 | - | - | - | - |
| Thyroid hormones | 1.434 | 0.706 | 2.912 | 0.319 | - | - | - | - |
| ACE inhibitors | 1.599 | 0.736 | 3.477 | 0.236 | - | - | - | - |
| Heparin group | 1.631 | 0.766 | 3.471 | 0.205 | - | - | - | - |
| Benzodiazepine derivatives | 1.540 | 0.660 | 3.593 | 0.318 | - | - | - | - |
| Selective serotonin reuptake inhibitors | 3.853 | 1.577 | 9.418 | 0.003 | 3.522 | 1.397 | 8.882 | 0.008 |
| Platelet aggregation inhibitors excl. heparin | 3.497 | 1.408 | 8.685 | 0.007 | 3.188 | 1.205 | 8.436 | 0.020 |