Table II.

Size Distribution of the Naloxone-PLGA Microparticles Made with Different Formulations and Homogenization Conditions

Formulation	Theoretical DL (%)	L:G ratio	Stator diameter (mm)-speed (RPM)-sieve size (μm)	D10 (μm)	D50 (μm)	D90 (μm)	Span
A50-L	30	50:50	10–5000–25	32.99	50.64	74.11	0.81
B50-L	40	50:50	10–5000–25	32.70	51.76	78.25	0.88
B50-S	40	50:50	25–3000–10	12.51	23.45	39.52	1.15
C50-L	50	50:50	10–5000–25	34.04	53.79	80.52	0.86
C50-S	50	50:50	25–3000–10	13.34	25.06	41.24	1.11
D50-L	60	50:50	10–5000–25	34.31	56.62	87.54	0.94
A75-L	30	75:25	10–5000–25	30.64	50.39	76.94	0.92
B75-L	40	75:25	10–5000–25	30.54	48.10	72.59	0.87
B75-S	40	75:25	25–3000–10	13.11	23.89	39.27	1.09
C75-L	50	75:25	10–5000–25	31.88	51.19	75.38	0.85
C75-S	50	75:25	25–3000–10	13.13	24.14	39.43	1.09
D75-L	60	75:25	10–5000–25	33.04	53.22	79.81	0.88