Skip to main content
. Author manuscript; available in PMC: 2021 Jun 10.
Published in final edited form as: Bioconjug Chem. 2020 Mar 6;31(3):542–546. doi: 10.1021/acs.bioconjchem.0c00062

Figure 2.

Figure 2.

Chemical compounds affect the genome editing efficiency of the AsCas12a-crRNAs system. (A) Effects of chemical compounds on gene-editing efficiency of AsCas12a-crDNMT1–3 in 293T cells. (B) Effects of compounds 1 and 2 on gene-editing efficiency of crDNMT1–3 in HEK293-AsCas12a cells. (C) Compound 1 increased gene-editing efficiency of AsCas12a-crDNMT1–3 in U87 cells. (D) Compound 1 increased the gene-editing efficiency of crFANCF-2 in HEK293-AsCas12a cells. (E) Effects of increased concentrations of compound 1 on gene-editing efficiency of crDNMT1–3 in HEK293-AsCas12a cells. Data are shown as mean ± SD (n = 3); *P < 0.05; **P < 0.01; ***P < 0.001, two-tailed t test.