Appendix 1—table 1. Top ranking gene candidates corresponding to Neanderthal AI in Europeans.
We show genes which overlap, or are within 100 kbp of, the 30 highest ranked 100 kbp intervals. Adjacent intervals have been merged. The CNN was trained using only AI simulations with selected mutation having allele frequency >5%, and subsequently calibrated with resampled neutral:sweep:AI ratios of 1:0.1:0.02 .c
| Chrom | Start | End | Genes |
|---|---|---|---|
| 1 | 39420001 | 39520000 | RRAGC; MYCBP; GJA9; RHBDL2; AKIRIN1; NDUFS5; MACF1 |
| 2 | 159880001 | 160280000 | TANC1; WDSUB1; BAZ2B |
| 2 | 180060001 | 180160000 | SESTD1 |
| 2 | 227800001 | 227900000 | RHBDD1; COL4A4 |
| 2 | 238820001 | 238960000 | LRRFIP1; RBM44; RAMP1; UBE2F; SCLY; ESPNL; KLHL30 |
| 3 | 114500001 | 114600000 | ZBTB20 |
| 5 | 57960001 | 58060000 | RAB3C |
| 6 | 28160001 | 28380000 | ZSCAN16-AS1; ZSCAN16; ZKSCAN8; ZSCAN9; ZKSCAN4; NKAPL; PGBD1; ZSCAN31; ZKSCAN3; ZSCAN12; ZSCAN23; GPX6 |
| 8 | 17060001 | 17160000 | MICU3; ZDHHC2; CNOT7; VPS37A; MTMR7 |
| 8 | 91840001 | 91940000 | TMEM64; NECAB1; TMEM55A |
| 9 | 16700001 | 16860000 | BNC2 |
| 10 | 11800001 | 11900000 | ECHDC3; PROSER2; UPF2 |
| 11 | 37740001 | 37840000 | |
| 19 | 20260001 | 20360000 | ZNF90; ZNF486 |
| 19 | 33580001 | 33700000 | RHPN2; GPATCH1; WDR88; LRP3; SLC7A10 |
| 20 | 14340001 | 14440000 | MACROD2; FLRT3 |