Table 3.

Effects of osteoporosis medications in patients with type 2 diabetes mellitus

Medication	Effect on glucose metabolism	BMD	Risk of fracture
Alendronate	Reduction in the risk of diabetes	Increase	NA/unchanged
Risedronate	Reduction in the risk of diabetes	Increase	NA
Etidronate	NA	NA	Unchanged
Denosumab	No effect on blood glucoselevels	Increase	Decrease
Raloxifene	Improves insulin sensitivity	NA	Decrease/unchanged
Teriparatide	No effect blood glucose levels	Increase	Unchanged

BMD: Bone mineral density; NA: Not available.