Table 4.
Blood glucose endpoints: 20 g liquid lactulose vs water
|
20 g liquid lactulose
|
Water
|
Treatment
|
P
value
|
|||
|
Variable
|
n
|
LS mean (95%CI)
|
n
|
LS mean (95%CI)
|
Difference (95%CI)
|
|
| AUCbaseline_c (0-180 min) (min/mmol/L) | 17 | -30.72 (-75.26, 13.83) | 16 | -53.21 (-99.14, -7.28) | 22.49 (-35.18, 80.16) | 0.4387 |
| AUC(0-180 min) (min/mmol/L) | 17 | 1242.02 (1197.47, 1286.56) | 16 | 1219.53 (1173.60, 1265.46) | 22.49 (-35.18, 80.16) | 0.4387 |
| iAUC(0-180 min) (min/mmol/L) | 17 | 34.42 (3.98, 64.86) | 16 | 18.44 (-13.04, 49.92) | 15.98 (26.78, 58.75) | 0.4578 |
| Cmax (mmol/L) | 17 | 7.747 (7.43, 8.06) | 16 | 7.44 (7.11, 7.77) | 0.31 (-0.12, 0.73) | 0.1560 |
| Max_increase (mmol/L) | 17 | 0.68 (0.36, 0.99) | 16 | 0.37 (0.043, 0.70) | 0.31 (-0.12, 0.73) | 0.1560 |
AUCbaseline_c (0-180 min): Baseline-corrected area under the curve from 0 to 180 min; AUC(0-180 min): Area under the curve from 0 to 180 min; iAUC(0-180 min): Incremental AUC(0-180 min), i.e., area above baseline levels of blood glucose concentration; Cmax: Maximum blood glucose concentration; Max_increase: Maximum blood glucose concentration minus baseline value; LS mean: Adjusted least square mean obtained from analysis of covariance model