Table 5.
Blood glucose endpoints: 30 g liquid lactulose vs water
|
30 g liquid lactulose
|
Water
|
Treatment
|
P
value
|
|||
|
Variable
|
n
|
LS mean (95%CI)
|
n
|
LS mean (95%CI)
|
Difference (95%CI)
|
|
| AUCbaseline_c (0-180 min) (min/mmol/L) | 15 | -41.01 (-88.72, 6.70) | 16 | -53.21 (-99.14, -7.28) | 12.20 (-47.48, 71.88) | 0.6843 |
| AUC(0-180 min) (min/mmol/L) | 15 | 1231.73 (1184.02, 1279.43) | 16 | 1219.53 (1173.60, 1265.46) | 12.20 (-47.48, 71.88) | 0.6843 |
| iAUC(0-180 min) (min/mmol/L) | 15 | 42.05 (9.51, 74.60) | 16 | 18.44 (-13.04, 49.92) | 23.61 (-20.52, 67.75) | 0.2890 |
| Cmax (mmol/L) | 15 | 8.07 (7.73, 8.41) | 16 | 7.44 (7.11, 7.77) | 0.63 (0.19, 1.07) | 0.0059 |
| Max_increase (mmol/L) | 15 | 1.00 (0.66, 1.34) | 16 | 0.37 (0.043, 0.70) | 0.63 (0.19, 1.07) | 0.0059 |
AUCbaseline_c (0-180 min): Baseline-corrected area under the curve from 0 to 180 min; AUC(0-180 min): Area under the curve from 0 to 180 min; iAUC(0-180 min): Incremental AUC(0-180 min), i.e., area above baseline levels of blood glucose concentration; Cmax: Maximum blood glucose concentration; Max_increase: Maximum blood glucose concentration minus baseline value; LS mean: Adjusted least square mean obtained from analysis of covariance model