Table 6.
Blood glucose endpoints: 30 g glucose vs 30 g liquid and crystal lactulose
|
|
Glucose 30 g
|
Liquid and crystal lactulose 30 g
|
Treatment
|
P
value
|
|||
|
Variable
|
n
|
LS mean (95%CI)
|
Formu-lation
|
n
|
LS mean (95%CI)
|
Difference (95%CI)
|
|
| AUCbaseline_c (0-180 min) (min/mmol/L) | 16 | 459.83 (413.74, 505.92) | Liquid | 15 | -41.01 (-88.72, 6.70) | 500.84 (439.43, 562.26) | < 0.0001 |
| Crystals | 16 | -30.70 (-76.75, 15.35) | 490.54 (431.89, 549.18) | < 0.0001 | |||
| AUC(0-180 min) (min/mmol/L) | 16 | 1732.57 (1686.48, 1778.66) | Liquid | 15 | 1231.73 (1184.02, 1279.43) | 500.84 (439.43, 562.26) | < 0.0001 |
| Crystals | 16 | 1242.03 (1195.98, 1288.08) | 490.54 (431.89, 549.18) | < 0.0001 | |||
| iAUC(0-180 min) (min/mmol/L) | 16 | 481.14 (449.56, 512.72) | Liquid | 15 | 42.05 (9.51, 74.60) | 439.08 (394.55, 483.62) | < 0.0001 |
| Crystals | 16 | 27.65 (-3.91, 59.21) | 453.49 (409.96, 497.02) | < 0.0001 | |||
| Cmax (mmol/L) | 16 | 13.22 (12.90, 13.55) | Liquid | 15 | 8.07 (7.73, 8.41) | 5.16 (4.71, 5.61) | < 0.0001 |
| Crystals | 16 | 7.77 (7.44, 8.09) | 5.46 (5.02, 5.89) | < 0.0001 | |||
| Max_increase (mmol/L) | 16 | 6.15 (5.83, 6.48) | Liquid | 15 | 1.00 (0.66, 1.34) | 5.16 (4.71, 5.61) | < 0.0001 |
| Crystals | 16 | 0.70 (0.37, 1.02) | 5.46 (5.02, 5.89) | < 0.0001 | |||
AUCbaseline_c (0-180 min): Baseline-corrected area under the curve from 0 to 180 min; AUC(0-180 min): Area under the curve from 0 to 180 min; iAUC(0-180 min): Incremental AUC(0-180 min), i.e., area above baseline levels of blood glucose concentration; Cmax: Maximum blood glucose concentration; Max_increase: Maximum blood glucose concentration minus baseline value; LS mean: Adjusted least square mean obtained from analysis of covariance model.