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. 2021 Jun 14;27(22):3073–3084. doi: 10.3748/wjg.v27.i22.3073

Figure 1.

Figure 1

The depletion of enhancer of zeste homolog 2 inhibits dextran sodium sulfate-induced colitis in vivo. A: The expression of enhancer of zeste homolog 2 (EZH2) was measured by quantitative real-time polymerase chain reaction in clinical inflammatory bowel disease (IBD) samples (n = 50) and healthy controls (n = 50); B-J: The IBD mouse model was conducted by adding dextran sodium sulfate (DSS). The mice were intraperitoneally injected with lentiviral plasmids carrying EZH2 shRNA; B: The expression of EZH2 was detected by quantitative real-time polymerase chain reaction in the mice; C: The protein levels of EZH2 were analyzed by Western blot in the mice; D: The body weight in the mice; E and F: Colon length of the mice; G: representative hematoxylin and eosin staining of distal colon sections; H-J: Colonic inflammatory cytokines in the mice. n = 10, mean ± SD. aP < 0.05; bP < 0.01; cP < 0.001. TNF-α: Tumor necrosis factor-α; IL: Interleukin.