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. 2021 Feb 8;39(6):737–746. doi: 10.1038/s41587-021-00815-9

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© The Author(s), under exclusive licence to Springer Nature America, Inc. 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — a, 3D reconstruction of the inner core. The endodermal cavities are depicted in different colors. The figure shows still images of Supplementary Video 5 at different time points. b, Comparison of HFOs with human embryonic hearts. Heat map generated from the microarray data of five HFOs versus four 5–7 weeks old human embryonic hearts and three hPSC samples (q≤0.01; variance filtering = 0.5; fold change ≥ 10 to view the 100 most significantly up-/ downregulated genes). c, Additional t-SNE plots showing the expression of the indicated genes in two combined d13 HFOs.