Table 1:
Patient Characteristics
| Double Positive | Discordant | Double Negative | Total | Significance | ||
|---|---|---|---|---|---|---|
| (n=377) | (n=23) | (n=67) | (n=467) | (P) | ||
| Demographics/Baseline Characteristics | ||||||
| Age, Mean years (SD) | 57 (9) | 57 (13) | 58 (11) | 57.1 (9.6) | 0.69 | |
| Sex, Male, N (%) | 342 (91) | 21 (91) | 48 (72) | 411 (88.0) | < 0.001 | |
| Race, Caucasian, N (%) | 360 (95) | 21 (91) | 45 (67) | 426 (91.2) | < 0.001 | |
| Smoking Status, N (%) | Never Smoker | 154 (41) | 7 (30) | 6 (9) | 167 (35.8) | < 0.001 |
| Former or Current Smoker | 221 (59) | 16 (70) | 61 (91) | 298 (63.8) | ||
| p16-Status, N (%) | Positive | 384 (82.2) | ||||
| Negative | 83 (17.8) | |||||
| HPV mRNA, N (%) | Positive | 393 (84.2) | ||||
| Negative | 74 (15.9) | |||||
| Initial Classification, N (%) | p16-negative/HPV-negative | 67 (14.4) | ||||
| p16-negative/HPV-positive | 16 (3.4) | |||||
| p16-positive/HPV-negative | 7 (1.5) | |||||
| p16-positive/HPV-positive | 377 (80.7) | |||||
| Clinical T Stage, N (%) | T0 - T2 | 286 (76) | 15 (65) | 31 (46) | 332 (71.1) | < 0.001 |
| T3 - T4 | 91 (24) | 8 (35) | 34 (51) | 133 (28.5) | ||
| Morphology, N (%) | Nonkeratinizing | 253 (67) | 7 (30) | 4 (6) | 264 (56.5) | < 0.001 |
| Nonkeratinizing with Maturation | 93 (25) | 11 (48) | 10 (15) | 114 (24.4) | ||
| Keratinizing | 10 (3) | 4 (17) | 52 (78) | 66 (14.1) | ||
| Other | 21 (6) | 1 (4) | 1 (1) | 23 (4.9) | ||
| Treatment, N (%) | Definitive Radiation | 122 (32) | 10 (43) | 27 (40) | 159 (34.1) | < 0.001 |
| Postoperative Radiation | 216 (57) | 11 (48) | 23 (34) | 250 (53.5) | ||
| Surgery Alone | 35 (9) | 0 (0) | 9 (13) | 44 (9.4) | ||
| Other | 4 (1) | 2 (9) | 8 (12) | 14 (3.0) | ||
| Chemotherapy, N (%) | 252 (67) | 18 (78) | 35 (52) | 305 (65.3) | 0.04 | |
| p16/HPV Reclassification, N (%) | Negative | 0 (0) | 3 (13) | 67 (100) | 70 (15.0) | < 0.001 |
| Positive | 376 (100) | 20 (87) | 0 (0) | 396 (84.8) | ||