Table 3:
Multivariable Survival Analysis: p16 and HPV mRNA testing (alone) groups
| Disease-Free Survival | HRR* | 95% CI | P |
|---|---|---|---|
| p16-negative (Reference category) | 1.00 | ||
| p16-positive | 0.33 | 0.22 – 0.49 | <0.001 |
| Age (HRR associated with an additional year of life) | 1.03 | 1.01 – 1.05 | 0.008 |
| Former or Current Smoker | 2.40 | 1.47 – 3.92 | <0.001 |
| T3/T4 | 1.54 | 1.03 – 2.31 | 0.04 |
| Definitive / Chemo only | 1.40 | 0.94 – 2.09 | 0.10 |
| Overall Survival | |||
| p16-negative (Reference category) | 1.00 | ||
| p16-positive | 0.30 | 0.20 – 0.46 | <0.001 |
| Age (HRR associated with an additional year of life) | 1.03 | 1.01 – 1.05 | 0.01 |
| Former or Current Smoker | 2.23 | 1.35 – 3.69 | 0.002 |
| T3/T4 | 1.66 | 1.09 – 2.53 | 0.02 |
| Definitive / Chemo Only | 1.56 | 1.03 – 2.36 | 0.04 |
| Disease-Free Survival | |||
| HPV mRNA Negative (Reference category) | 1.00 | ||
| HPV mRNA Positive | 0.29 | 0.20 – 0.43 | <0.001 |
| Age (HRR associated with an additional year of life) | 1.03 | 1.01 – 1.05 | 0.002 |
| Former or current smoker | 2.29 | 1.41 – 3.74 | 0.001 |
| T3/T4 | 1.66 | 1.12 – 2.46 | 0.012 |
| Definitive / Chemo only | 1.48 | 1.00 – 2.19 | 0.05 |
| Overall Survival | |||
| HPV mRNA Negative (Reference category) | 1.00 | ||
| HPV mRNA Positive | 0.26 | 0.17 – 0.39 | <0.001 |
| Age (HRR associated with an additional year of life) | 1.04 | 1.01 – 1.06 | 0.002 |
| Former or current smoker | 2.14 | 1.29 – 3.54 | 0.003 |
| T3/T4 | 1.84 | 1.22 – 2.77 | 0.003 |
| Definitive / Chemo only | 1.69 | 1.12 – 2.54 | 0.01 |
*
Hazard Rate Ratio