Table 1.
Major exclusion criteria of common conditions in people with cystic fibrosis for the elexacaftor/tezacaftor/ivacaftor trials.(2, 3)
| ■ppFEV1 <40 |
| ■Clinically significant cirrhosis with or without portal hypertension |
| ■Solid organ or hematological transplantation |
| ■Pregnant or nursing females |
| ■Lung infection with Burkholderia cenocepacia, B. dolosa, and Mycobacterium abscessus |
| ■Single copy of F508del without a second identified CFTR mutation |
ppFEV1 = percent predicted forced expiratory volume in one second; CFTR = cystic fibrosis transmembrane conductance regulator