Table 2:

Association among 314 dolutegravir recipients between percentage weight gain at week 48 and selected polymorphisms relevant to dolutegravir

SNPa	Gene	MAFc	Beta	P-valued
rs13137622	ABCG2	0.46	−1.24	0.03
rs2725252	ABCG2	0.19	−1.29	0.06
rs1042640	UGT1A1	0.18	1.34	0.07
rs10929302	UGT1A1	0.29	1.01	0.09
rs28401781	ABCB1	0.25	−1.12	0.09
rs2246709	CYP3A4	0.31	−0.94	0.12
rs1976391	UGT1A1	0.41	0.84	0.13
rs887829b	UGT1A1	0.41	0.81	0.15
rs2231137	ABCG2	0.06	1.73	0.16
rs10011796	ABCG2	0.25	−0.92	0.16
rs12505410	ABCG2	0.1	−1.1	0.24
rs4148738	ABCB1	0.14	−0.89	0.25
rs4124874	UGT1A1	0.37	0.92	0.26
rs3789243	ABCB1	0.38	0.66	0.27
rs1922242	ABCB1	0.45	0.59	0.28
rs10276036	ABCB1	0.15	−0.81	0.28
rs1045642	ABCB1	0.89	0.93	0.35
rs3842	ABCB1	0.28	0.55	0.36
rs2235015	ABCB1	0.36	0.47	0.41
rs3213619	ABCB1	0.17	0.55	0.47
rs10248420	ABCB1	0.35	0.4	0.5
rs2235067	ABCB1	0.15	−0.42	0.6
rs10267099	ABCB1	0.1	0.49	0.6
rs1128503	ABCB1	0.06	0.59	0.61
rs2740574	CYP3A4	0.25	−0.3	0.62
rs11983225	ABCB1	0.21	−0.26	0.72
rs3735451	CYP3A4	0.17	0.24	0.76
rs4646440	CYP3A4	0.08	−0.28	0.78
rs4728709	ABCB1	0.39	0.15	0.79
rs4148740	ABCB1	0.19	−0.17	0.81
rs2242480	CYP3A4	0.14	0.19	0.82
rs7699188	ABCG2	0.44	−0.12	0.83
rs3114020	ABCG2	0.15	−0.17	0.83
rs8330	UGT1A1	0.4	0.12	0.84
rs10280101	ABCB1	0.2	−0.11	0.88
rs4646437	CYP3A4	0.13	0.09	0.92
rs2235047	ABCB1	0.23	−0.05	0.94
rs10929303	UGT1A1	0.37	−0.03	0.95
rs7787082	ABCB1	0.27	−0.02	0.97
rs2235040	ABCB1	0.17	−0.02	0.98

^aSNP: Single nucleotide polymorphism.

^bUGT1A1 rs887829 T allele is known to be in strong linkage disequilibrium (LD) with the Gilbert trait decrease expression allele, UGT1A1*28.

^cMAF: Minor allele frequency.

^dSignificance threshold was 1.0×10⁻³ for the subset of 40 polymorphisms.