Table 1: Heritability of Network Connectome Structure in the HCP Dataset.
Twin correlations and ACE structural equation model estimates are displayed. For correlation analyses, heritability is suggested when the correlation between MZ twins is greater than the correlation between DZ twins. ACE variances were unbounded so could be negative. The upper and lower bound of the likelihood-based 95% confidence intervals are displayed inside the squared brackets for the A, C and E parameters. AIC= Akaike’s information criterion, a measure of model fit; lower AIC values indicate better fit, marked in bold in the table.
| Measure | Twin correlations | ACE Structural Models | ||||||
|---|---|---|---|---|---|---|---|---|
| rmz | rdz | Diff | Model | A [A−,A+] | C [C−,C+] | E [E−,E+] | AIC | |
| Characteristic path length | 0.573 | 0.393 | 0.18 | ACE | 0.287 [−0.15,0.83] | 0.26[−0.26,0.64] | 0.45[0.35,0.59] | 326.274 |
| AE | 0.56 [0.43,0.66] | NA | 0.44 [0.34,0.57] | 325.388 | ||||
| CE | NA | 0.5[0.39,0.6] | 0.5 [0.4,0.61] | 325.854 | ||||
| E | NA | NA | 1 | 375.020 | ||||
| Clustering Coefficient | 0.485 | 0.255 | 0.23 | ACE | 0.49[0.04,0.59] | −0.03[−0.59,0.44] | 0.54 [0.42,0.69] | 341.632 |
| AE | 0.46 [0.32,0.58] | NA | 0.54[0.41,0.68] | 339.644 | ||||
| CE | NA | 0.39[0.26,0.51] | 0.61[0.49, 0.74] | 342.912 | ||||
| E | NA | NA | 1 | 369.665 | ||||
| Global efficiency | 0.291 | 0.101 | 0.19 | ACE | 0.44 [0.16,1.06] | −0.17[−0.72,0.35] | 0.72[0.57,0.89] | 417.56 |
| AE | 0.26 [0.1,0.41] | NA | 0.74[0.59,0.9] | 415.929 | ||||
| CE | NA | 0.21[0.06,0.34] | 0.79[0.66,0.94] | 417.642 | ||||
| E | NA | NA | 1 | 423.465 | ||||
| Local efficiency | 0.411 | 0.151 | 0.26 | ACE | 0.44[0.14,1.08] | −0.05[−0.64,0.45] | 0.62[0.48,0.77] | 375.833 |
| AE | 0.38 [0.23,0.52] | NA | 0.62[0.48,0.77] | 373.866 | ||||
| CE | NA | 0.33 [0.19,0.45] | 0.67[0.55,0.81] | 376.0203 | ||||
| E | NA | NA | 1 | 393.164 | ||||
| Modularity | 0.287 | −0.045 | 0.33 | ACE | 0.65 [0.07,1.22] | −0.34[−0.83,0.14] | 0.69 [0.53,0.87] | 345.842 |
| AE | 0.26[0.09,0.43] | NA | 0.73[O.57,0.91] | 345.741 | ||||
| CE | NA | 0.17[0.03,0.31] | 0.83[0.69,0.97] | 348.758 | ||||
| E | NA | NA | 1 | 352.092 | ||||
| Small Worldness | −0.095 | −0.032 | −0.06 | ACE | −0.1[−0.72,0.51] | 0 [−0.51,0.51] | 1.1[0.91,1.28] | 437.859 |
| AE | −0.1 [−0.27,0.08] | NA | 1.1[0.92,1.27] | 435.859 | ||||
| CE | NA | −0.08 [−0.23,0.07] | 1.08[0.93,1.23] | 435.957 | ||||
| E | NA | NA | 1 | 435.06 | ||||