Table 4: Heritability of Brain Network Resilience in the LTS Dataset.
Twins’ correlations and ACE structural equation model estimates are displayed. For correlation analyses, heritability is suggested when the correlation between MZ twins is greater than the correlation between DZ twins. ACE variances were unbounded so could be negative. The upper and lower bound of the likelihood-based 95% confidence intervals are displayed inside the squared brackets for the A, C and E parameters. AIC = Akaike’s information criterion, a measure of model fit; lower AIC values indicate better fit, marked in bold in the table. The models did not converge for the measures of Targeted Edge Removal and Speed of Drop.
| Measure | Twins’ Correlations | ACE Structural Model | ||||||
|---|---|---|---|---|---|---|---|---|
| r mz | rdz | Diff | Model | A [A−,A+] | C [C−,C+] | E [E−,E+] | AIC | |
| Random Node Removal | 0.045 | −0.007 | 0.05 | ACE | 0.14[−0.45,0.71] | −0.09[−0.52,0.35] | 0.95[0.74,1.17] | 417.629 |
| AE | 0.03[0.16,0.22] | NA | 0.97[0.78,1.16] | 415.783 | ||||
| CE | NA | 0.01[−0.13,0.15] | 0.99[0.84,1.13] | 415.85 | ||||
| E | NA | NA | 1 | 413.875 | ||||
| Targeted Node Removal | −0.076 | 0.092 | −0.17 | ACE | −0.35[−0.93,0.27] | 0.25[−0.17,0.66] | 1.1[0.84,1.33] | 461.323 |
| AE | 0[−0.2,0.2] | NA | 1[0.8,1.2] | 460.692 | ||||
| CE | NA | 0.03[−0.11,0.16] | 0.97[0.8,1.11] | 460.563 | ||||
| E | NA | NA | 1 | 458.693 | ||||
| Targeted Edge Removal | 0.045 | 0.15 | −0.1 | ACE | NA | NA | NA | |
| AE | NA | NA | NA | |||||
| CE | NA | NA | NA | |||||
| E | NA | NA | NA | |||||
| Speed of Drop | −0.069 | −0.013 | −0.06 | ACE | NA | NA | NA | |
| AE | NA | NA | NA | |||||
| CE | NA | NA | NA | |||||
| E | NA | NA | NA | |||||
| Early Edges Drop | −0.21 | −0.004 | −0.21 | ACE | −0.38[−0.95,0.19] | 0.19[−0.29,0.66] | 1.19[1.01,1.36] | 368.881 |
| AE | −0.16[0.33,0] | NA | 1.17[0.99,1.33] | 367.452 | ||||
| CE | NA | −0.11[−0.25,0.02] | 1.12[0.98,1.26] | 368.586 | ||||
| E | NA | NA | 1 | 369.298 | ||||
| Critical Point | 0.054 | 0.025 | 0.03 | ACE | 0.12[−0.52,0.72] | −0.03[−0.47,0.41] | 0.92[0.68,1.18] | 324.655 |
| AE | 0.07[0.13,0.27] | NA | 0.93[0.73,1.14] | 322.678 | ||||
| CE | NA | 0.41[−0.1,0.19] | 0.96[0.81,1.1] | 322.784 | ||||
| E | NA | NA | 1 | 321.1 | ||||
| Late Edges Drop | 0.022 | 0.048 | −0.03 | ACE | 0[−0.65,0.63] | 0.04[−0.39,0.48] | 0.96[0.69,1.23] | 317.146 |
| AE | 0.06[−0.15,0.27] | NA | 0.94[0.73,1.15] | 315.182 | ||||
| CE | NA | 0.04[−0.1,0.18] | 0.96[0.82,1.1] | 315.146 | ||||
| E | NA | NA | 1 | 313.507 | ||||