Table 1 |.
Genome-wide significant loci for bipolar disorder from meta-analysis of 41,917 cases and 371,549 controls
| Locus | CHR | BP | SNP | P | OR | s.e. | A1/A2 | A1 freq in controls | Previous report^ for BD (citation) | Name for novel locus+ | Previous report^ for psychiatric disorders |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 1 | 61105668 | rs2126180 | 1.6E-09 | 1.058 | 0.009 | A/G | 0.457 | LINC01748 | ||
| 2 | 1 | 163745389 | rs10737496 | 7.2E-09 | 1.056 | 0.009 | C/T | 0.444 | NUF2 | CDG | |
| 3* | 2 | 97416153 | rs4619651 | 4.8E-11 | 1.068 | 0.010 | G/A | 0.670 | LMAN2L (PGC2) | CDG | |
| 4 | 2 | 166152389 | rs17183814 | 2.7E-08 | 1.108 | 0.019 | G/A | 0.924 | SCN2A (PGC2) | ||
| 5 | 2 | 169481837 | rs13417268 | 2.1E-08 | 1.064 | 0.011 | C/G | 0.758 | CERS6 | ||
| 6 | 2 | 193738336 | rs2011302 | 4.3E-08 | 1.055 | 0.010 | A/T | 0.377 | PCGEM1 | CDG | |
| 7 | 2 | 194437889 | rs2719164 | 4.9E-08 | 1.053 | 0.010 | A/G | 0.564 | intergenic (PGC2) | CDG | |
| 8* | 3 | 36856030 | rs9834970 | 6.6E-19 | 1.087 | 0.009 | C/T | 0.481 | TRANK1 (PGC2) | SCZ, CDG | |
| 9* | 3 | 52626443 | rs2336147 | 3.6E-13 | 1.070 | 0.009 | T/C | 0.498 | ITIH1 (PGC2) | SCZ, CDG | |
| 10 | 3 | 70488788 | rs115694474 | 2.4E-08 | 1.068 | 0.012 | T/A | 0.799 | MDFIC2 | ||
| 11 | 3 | 107757060 | rs696366 | 4.5E-08 | 1.053 | 0.009 | C/A | 0.550 | CD47 (PGC2) | ||
| 12* | 4 | 123076007 | rs112481526 | 1.9E-09 | 1.065 | 0.011 | G/A | 0.256 | KIAA1109 | MD | |
| 13* | 5 | 7542911 | rs28565152 | 2.0E-09 | 1.070 | 0.011 | A/G | 0.238 | ADCY2 (PGC2) | ||
| 14* | 5 | 78849505 | rs6865469 | 1.7E-08 | 1.060 | 0.010 | T/G | 0.274 | HOMER1 | ||
| 15 | 5 | 80961069 | rs6887473 | 8.8E-09 | 1.062 | 0.011 | G/A | 0.739 | SSBP2 (PGC2) | ||
| 16* | 5 | 137712121 | rs10043984 | 3.7E-08 | 1.062 | 0.011 | T/C | 0.236 | KDM3B | CDG | |
| 17 | 5 | 169289206 | rs10866641 | 2.8E-11 | 1.065 | 0.009 | T/C | 0.575 | DOCK2 | ||
| 18* | 6 | 26463575 | rs13195402 | 5.8E-15 | 1.146 | 0.018 | G/T | 0.919 | MHC | MD, SCZ, CDG, MOOD | |
| 19* | 6 | 98565211 | rs1487445 | 1.5E-15 | 1.078 | 0.009 | T/C | 0.487 | POU3F2 (PGC2) | CDG | |
| 20 | 6 | 152793572 | rs4331993 | 2.0E-08 | 1.056 | 0.010 | A/T | 0.382 | SYNE1 (Green 2013) | ||
| 21* | 6 | 166995260 | rs10455979 | 4.2E-09 | 1.057 | 0.010 | G/C | 0.500 | RPS6KA2 (PGC2) | ||
| 22* | 7 | 2020995 | rs12668848 | 1.9E-09 | 1.059 | 0.010 | G/A | 0.575 | MAD1L1 (Hou 2016, Ikeda 2017) | MD, SCZ, CDG | |
| 23* | 7 | 11871787 | rs113779084 | 1.4E-13 | 1.079 | 0.010 | A/G | 0.299 | THSD7A (PGC2) | ||
| 24* | 7 | 21492589 | rs6954854 | 5.9E-10 | 1.060 | 0.009 | G/A | 0.425 | SP4 | ||
| 25 | 7 | 24647222 | rs12672003 | 2.7E-09 | 1.096 | 0.016 | G/A | 0.113 | MPP6 | SCZ, CDG, MOOD | |
| 26 | 7 | 105043229 | rs11764361 | 3.5E-09 | 1.063 | 0.010 | A/G | 0.668 | SRPK2 (PGC2) | SCZ, ASD, CDG | |
| 27 | 7 | 131870597 | rs6946056 | 3.7E-08 | 1.055 | 0.010 | C/A | 0.623 | PLXNA4 | ||
| 28 | 7 | 140676153 | rs10255167 | 1.6E-08 | 1.068 | 0.012 | A/G | 0.778 | MRPS33 (PGC2) | CDG | |
| 29* | 8 | 9763581 | rs62489493 | 2.6E-11 | 1.094 | 0.014 | G/C | 0.128 | miR124–1 | SCZ, ALC, ASD | |
| 30* | 8 | 10226355 | rs3088186 | 2.1E-08 | 1.058 | 0.010 | T/C | 0.287 | MSRA | SCZ, ALC, ASD | |
| 31 | 8 | 34152492 | rs2953928 | 6.3E-09 | 1.124 | 0.020 | A/G | 0.067 | RP1–84O15.2 (lincRNA) | SCZ, ADHD, CDG | |
| 32* | 8 | 144993377 | rs6992333 | 1.6E-09 | 1.062 | 0.010 | G/A | 0.410 | PLEC | ||
| 33 | 9 | 37090538 | rs10973201 | 2.5E-08 | 1.101 | 0.017 | C/T | 0.110 | ZCCHC7 | MD, CDG, MOOD | |
| 34* | 9 | 141066490 | rs62581014 | 2.8E-08 | 1.067 | 0.012 | T/C | 0.366 | TUBBP5 | ||
| 35* | 10 | 18751103 | rs1998820 | 4.1E-08 | 1.087 | 0.015 | T/A | 0.886 | CACNB2 | SCZ, CDG | |
| 36* | 10 | 62322034 | rs10994415 | 1.1E-11 | 1.125 | 0.017 | C/T | 0.082 | ANK3 (PGC2) | ||
| 37 | 10 | 64525135 | rs10761661 | 4.7E-08 | 1.053 | 0.009 | T/C | 0.472 | ADO | ||
| 38* | 10 | 111648659 | rs2273738 | 1.6E-11 | 1.096 | 0.014 | T/C | 0.135 | ADD3 (Charney 2017, PGC2) | ||
| 39* | 11 | 61618608 | rs174592 | 9.9E-14 | 1.074 | 0.010 | G/A | 0.395 | FADS2 (PGC2) | MD, CDG, MOOD | |
| 40 | 11 | 64009879 | rs4672 | 3.4E-09 | 1.107 | 0.017 | A/G | 0.083 | FKBP2 | ||
| 41* | 11 | 65848738 | rs475805 | 2.0E-09 | 1.070 | 0.011 | A/G | 0.767 | PACS1 (PGC2) | ||
| 42* | 11 | 66324583 | rs678397 | 5.5E-09 | 1.056 | 0.009 | T/C | 0.457 | PC (PGC1, PGC2) | ||
| 43* | 11 | 70517927 | rs12575685 | 1.2E-10 | 1.067 | 0.010 | A/G | 0.327 | SHANK2 (PGC2) | MD | |
| 44 | 11 | 79092527 | rs12289486 | 3.3E-08 | 1.086 | 0.015 | T/C | 0.115 | ODZ4 (PGC1) | ||
| 45* | 12 | 2348844 | rs11062170 | 1.9E-15 | 1.081 | 0.010 | C/G | 0.333 | CACNA1C (PGC2) | SCZ, CDG, MOOD | |
| 46 | 13 | 113869045 | rs35306827 | 3.6E-09 | 1.068 | 0.011 | G/A | 0.775 | CUL4A | ||
| 47 | 14 | 99719219 | rs2693698 | 2.0E-08 | 1.055 | 0.009 | G/A | 0.551 | BCL11B | SCZ, CDG | |
| 48* | 15 | 38973793 | rs35958438 | 3.8E-08 | 1.066 | 0.012 | G/A | 0.772 | C15orf53 | CDG | |
| 49* | 15 | 42904904 | rs4447398 | 2.6E-09 | 1.086 | 0.014 | A/C | 0.131 | STARD9 (PGC2) | ||
| 50 | 15 | 83531774 | rs62011709 | 1.4E-08 | 1.064 | 0.011 | T/A | 0.747 | HOMER2 | SCZ | |
| 51* | 15 | 85149575 | rs748455 | 5.0E-11 | 1.070 | 0.010 | T/C | 0.719 | ZNF592 (PGC2) | SCZ, CDG | |
| 52 | 15 | 91426560 | rs4702 | 3.5E-09 | 1.059 | 0.010 | G/A | 0.446 | FURIN | SCZ, CDG | |
| 53 | 16 | 9230816 | rs28455634 | 2.6E-10 | 1.065 | 0.010 | G/A | 0.620 | C16orf72 | ||
| 54 | 16 | 9926348 | rs7199910 | 1.7E-08 | 1.057 | 0.010 | G/T | 0.312 | GRIN2A (PGC2) | SCZ, CDG | |
| 55 | 16 | 89632725 | rs12932628 | 6.7E-09 | 1.058 | 0.010 | T/G | 0.487 | RPL13 | ||
| 56 | 17 | 1835482 | rs4790841 | 3.1E-08 | 1.075 | 0.013 | T/C | 0.151 | RTN4RL1 | ||
| 57 | 17 | 38129841 | rs11870683 | 2.8E-08 | 1.059 | 0.010 | T/A | 0.650 | ERBB2 (Hou 2016) | ||
| 58 | 17 | 38220432 | rs61554907 | 1.6E-08 | 1.091 | 0.015 | T/G | 0.124 | ERBB2 (Hou 2016) | ||
| 59* | 17 | 42191893 | rs228768 | 2.8E-10 | 1.067 | 0.010 | G/T | 0.294 | HDAC5 (PGC2) | ||
| 60* | 20 | 43682551 | rs67712855 | 4.2E-11 | 1.070 | 0.010 | T/G | 0.687 | STK4 (PGC2) | ||
| 61* | 20 | 43944323 | rs6032110 | 1.0E-09 | 1.059 | 0.009 | A/G | 0.512 | WFDC12 (PGC2) | ||
| 62* | 20 | 48033127 | rs237460 | 4.3E-09 | 1.057 | 0.009 | T/C | 0.412 | KCNB1 | CDG | |
| 63 | 20 | 60865815 | rs13044225 | 8.5E-09 | 1.056 | 0.010 | G/A | 0.440 | OSBPL2 | ||
| 64 | 22 | 41153879 | rs5758064 | 2.0E-08 | 1.054 | 0.009 | T/C | 0.523 | SLC25A17 | MD, SCZ, CDG, MOOD |
CHR, chromosome; BP, GRCh37 base pair position; SNP, single nucleotide polymorphism; OR, odds ratio; s.e., standard error, A1, tested allele; A2, other allele; freq, frequency; BD, bipolar disorder; CDG, Cross-disorder GWAS of the Psychiatric Genomics Consortium; MD, major depression; SCZ, schizophrenia; MOOD, mood disorders; ASD, autism spectrum disorder; ALC, alcohol use disorder or problematic alcohol use; ADHD, attention deficit/hyperactivity disorder.
*
Locus overlaps with genome-wide significant locus for bipolar I disorder.
^
Previous report refers to previous association of a SNP in the locus with the psychiatric disorder at genome-wide significance. PGC1 = PMID 21926972; PGC2 = PMID 31043756; Hou 2016 = PMID 27329760; Ikeda 2017 = PMID 28115744; Green 2013 = PMID 22565781; Charney 2017 = PMID 28072414.
+
Novel loci are named using the nearest gene to the index SNP. P values are two-sided and based on an inverse variance weighted fixed effects meta-analysis.