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The 3D printed porous HA scaffold coated with BMP-2 loaded chitosan microspheres used for bone regeneration. A. Design, photograph and SEM images of 3D printed porous HA scaffold, collagen coated scaffold (HC) and collagen coated scaffold with BMP-2 loaded chitosan microspheres (HCC); B. in vitro release profile of BMP-2 from HCC; C. μCT images of ectopic bone formation with HCC after implantations for 4 week and 8 weeks. Reproduced with permission.[141] Copyright 2016, Elsevier.
