Table 1:
Hypothalamic expression of BDNF and it’s receptors*
| NGFR (p75NTR) | NTRK2 (TrkB) | BDNF | Refs | |
|---|---|---|---|---|
| Paraventricular hypothalamic nucleus (PVH) | - | Moderate | Moderate | TrkB: [42] BDNF: [43,46] |
| Periventricular hypothalamic nucleus (PV) | - | Low | - | |
| Arcuate hypothalamic nucleus (ARC) | Low | Moderate | Not expressed in ARC, but has been shown to alter ARC neuron structure | p75NTR: [14] BDNF: [46] |
| Anteroventral periventricular nucleus (AVPV) | - | Moderate | High | |
| Dorsomedial nucleus of the hypothalamus (DMH) | Moderate to Low | Moderate | Moderate | TrkB: [40] BDNF: [37] |
| Medial preoptic area (MPO) | - | Low | High | BDNF: [44] |
| Periventricular hypothalamic nucleus, posterior part (PVp) | Moderate | Moderate | - | |
| Suprachiasmatic nucleus (SCH) | - | Moderate | - | |
| Mammillary body (MBO) | - | - | Moderate to Low | |
| Ventral premammillary nucleus (PMv) | Moderate | Moderate | - | |
| Ventromedial hypothalamic nucleus (VMH) | - | Low | Moderate | BDNF: [37] |
| Posterior hypothalamic nucleus (PH) | - | Low | Moderate | |
| Lateral hypothalamic area (LHA) | - | Low | Low | |
| Parasubthalamic nucleus (PSTN) | Low | - | Low | |
| Retrochiasmatic area (RCH) | - | Moderate | - | |
| Tuberal nucleus (TU) | Moderate to Low | Moderate | - | |
| Zona incerta (ZI) | - | Low | - |
*
NGFR- nerve growth factor receptor, gene name for p75NTR. NTRK2- neurotrophin receptor tyrosine kinase 2, gene name for TrkB. (-) indicates expression not observed.