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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Trends Endocrinol Metab. 2021 May 4;32(7):488–499. doi: 10.1016/j.tem.2021.04.005

Table I:

Summary of Neurotrophins' Metabolic Roles

NGF (TrkA, p75NTR) BDNF (TrkB, p75NTR) NT3 (TrkC, p75NTR) NT4 (TrkB, p75NTR) Refs
Central administration Reduces feeding Reduces feeding Unknown Reduces Feeding NGF: [82,89]
BDNF: [82]
NT4: [59]
Mouse mutant Unknown Obese and hyperphagic (same in humans) Normal weight Normal weight BDNF: [59], [21]
NT3: [59]
NT4: [59]
TrkA (NGF) TrkB (BDNF, NT4) TrkC (NT3) p75NTR (NGF, BDNF, NT3, NT4)
Human mutant Unknown Obese and hyperphagic Association with eating disorders Unknown TrkB: [16]
TrkC: [85]
Mouse mutant Impaired insulin secretion and glucose tolerance Obese and hyperphagic Normal weight Resistance to weight gain on HFD; decreased refeeding after fasting TrkA: [88]
TrkB: [15]
TrkC: [59]
p75NTR: [13,14]