Figure 4. Innate Immune Signaling Pathways Are Required for Resistance against Colitis and Colon Cancer in Tak1^∆M/∆M Mice.

(A-B) Serum IL-6 and IL-1β in WT, Tak1^∆M/∆M, and Abx-treated Tak1^∆M/∆M mice (for 4 weeks).

(C-D) Body weight changes and survival of different strains after 5% DSS treatment.

(E-F) Colon tumors in different strains on day 80 after AOM/DSS treatment, tumor number analysis, and Ki-67 positive cells on colon sections.

(G-H) The 16S rRNA gene profiling data for fecal microbiome from WT, Tak1^∆M/∆M, and double knockout mice. (G) PCoA plot of bacterial beta-diversity. (H) Relative abundance of significantly altered taxa at genus level, including unspecified taxa.

Statistical analyses: Student’s unpaired t test (A-C, E, and F), Monte Carlo permutation test (G), and Mantel-Cox log-rank test (D). *p<0.05; **p<0.01; ***p<0.001; ****p<0.0001.

See also Figure S4 and Table S2.