Fig. 1.

The landscape of NRUs structures using experimental nextPARS data. A. Overview of the nextPARS experiments. NORAD fragments were probed in three RNA fragments covering the full-length NORAD lncRNA (overlapping 1903, 1862 and 1614 bases, respectively), and 11 NRUs with their surrounding regions (overlapping 179 nt each). B. On the top, an arc plot depicting the interactions of the secondary structure inferred from the nextPARS profiles using RNAstructure software. The core sequences of the NRUs (89nt) are marked alongside NORAD. On the bottom, the secondary structure of NRUs derived from the full-length NORAD nextPARS experiment. Scores from full-length NORAD nextPARS profiles are depicted by colored nucleotides.