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. Author manuscript; available in PMC: 2022 Jun 10.
Published in final edited form as: J Med Chem. 2021 Apr 21;64(11):7275–7295. doi: 10.1021/acs.jmedchem.1c00168

Table 2.

Summary of HP Cytotoxicity against HeLa, J774 MΦ, Hep G2, and HEK-293 Cell Linesa,b

compound MRSA-1707 MIC HeLa cytotox. (IC50) J774 MΦ cytotox. (IC50) Hep G2 cytotox. (IC50) HEK-293 cytotox. (IC50)
3 1.56 >100 >100 >100
21 0.30 >100 >200 >200
24 0.30 >100 >200 >200
27 0.78 100
28 0.15 >100 >200 >200
29 0.08 >100 >200 >200 18.3 ± 5.8
30 0.08 >200 >200
31 0.59 >200 >200
32 0.15 >100 >200 >200
33 0.15 >25 >200 >200
34 0.59 >100 >200 >200
35 0.30 100 >200 >200
45 0.30 >100 >200
a

All results are reported in micromolar (μM) concentrations.

b

Assay information: HeLa cytotoxicity (24 h, LDH release assay), J774 MΦ cytotoxicity (24 h, Alamar Blue assay), HepG2 cytotoxicity (24 h, Alamar Blue assay), HEK-293 cytotoxicity (72 h, MTT assay).

Note: All experimental results are reported from a minimum of three independent cytotoxicity experiments.