IHK mice manifest elevated anxiety-like behaviors and memory impairment. (A, B, C) Object location memory (OLM) test. A sham control mouse that explored objects during training and testing (A). Summary of DI (B) and exploration time (C). (D, E, F) Open field test. Heatmap of location of a sham control and an IHK mouse during testing period (D). Summary of center time (E) and exploration distance (F). The numbers above the bars indicate the number of mice used for OLM test or open field test; * indicates p < 0.05; *** indicates p < 0.001; ns, not significant.