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. 2021 Jun 10;12:3516. doi: 10.1038/s41467-021-23583-1

Fig. 7. Reduced fibroblast numbers and collagen deposition.

Fig. 7

a Analysis of intra-tumoural αSMA positive staining in 4T1, D2A1 and D2A1-m2 primary tumours grown in Endo180+/+ and Endo180−/− mice. Data represents mean values per tumour ± SEM (4T1, n = 5 per group; D2A1, Endo180+/+ n = 4, Endo180−/− n = 5; D2A1-m2, Endo180+/+ n = 6, Endo180−/− n = 7; two-sided t-test) Representative images (scale bar, 100 µm). b Analysis of intra-tumoural Masson’s trichrome staining of 4T1 (left panel) and D2A1-m2 (right panel) primary tumours in Endo180+/+ and Endo180−/− mice. Data represent mean values per tumour ±SEM (4T1, n = 5 per group; D2A1-m2, Endo180+/+ n = 7, Endo180−/− n = 6; two-sided t-test). Representative images (scale bar, 100 µm). c Analysis of intra-tumoural F4/80 staining of D2A1-m2 primary tumours in Endo180+/+ and Endo180−/− mice. Data represent mean values per tumour ±SEM (n = 6 per group; two-sided t-test). Representative images (scale bar, 100 µm). d Analysis of intra-tumoural endomucin staining of D2A1-m2 primary tumours. Data represent mean values per tumour ±SEM (Endo180+/+ n = 7, Endo180−/− n = 6; two-sided t-test). Representative images (scale bar, 100 µm). Non-significant (ns) P values > 0.05. Source data are provided as a Source Data file.