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. 2021 Jun 10;4:717. doi: 10.1038/s42003-021-02238-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Proportions of A–I RNA-editing sites across genic regions. b Proportions of A–I RNA-editing sites within repeat regions. c Proportions of A–I RNA-editing sites within SINE/tRNA elements (only top 5 elements were shown). d Distribution of RNA-editing levels. e Percentages of editing sites occurring in clusters (at least three sites within a 100 bp window) across intron, 5′-UTR, 3′-UTR, and CDS. f Percentages of editing sites occurring in clusters (at least three sites within a 100 bp window) in SINE/tRNA and LINE1 elements. The number of biological replicates is 119. Bar denotes Median + IQR. g Frequency of nucleotides in the flanking sequences (5 bp upstream and downstream) of the editing sites and randomly selected genomic “A” sites. h The top Gene Ontology (GO) terms associated with genes harboring recoding sites.