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. 2021 Jun 10;4:717. doi: 10.1038/s42003-021-02238-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a PCA on editing levels of conserved editing sites across various brain regions between pig and human. The subregions in human brain are as follows: amygdala, am; anterior cingulate cortex, acg; caudate, cn; cerebellar hemisphere, cbh; cerebellum, cb; cortex, c; frontal cortex, fr; hippocampus, hc; hypothalamus, hy; nucleus accumbens, na; putamen, pu; spinal cord, spc; and substantia nigra, sn. The subregions in pig brain are as follows: olfactory bulb, ob; cingulate cortex, cg; motor cortex, mo; prefrontal cortex, pf; retrosplenial cortex, rt; somatosensory cortex, ss; temporal lobe, tp; insula cortex, in; occipital lobe, oc; amygdala, am; entorhinal cortex, en; hippocampus dorsal, hd; hippocampus ventral, hv; subiculum, sb; caudate nucleus, cn; putamen, pu; septum, sep; ventral pallidum, vp; hypothalamus, hy; thalamus, th; midbrain, mb; periaqueductal gray, pg; superior colliculus, sc; substantia nigra, sn; medulla oblongata, my; pons, po; cerebellum, cb; corpus callosum, cc; spinal cord dorsal, sd; and spinal cord ventral, sv. The subregions are organized into 12 main regions, including Olfactory bulb, OLF; Cerebral cortex, CTX; Amygdala, AMY; Hippocampal formation, HPF; Basal ganglia, BG; Hypothalamus, HY; Thalamus, TH; Midbrain, MB; Pons and medulla, PM; Cerebellum, CB; Corpus callosum, CC; and Spinal cord, SC. b Comparisons of conserved editing sites across six brain regions, including the cerebral cortex, amygdala, hippocampal formation, hypothalamus, cerebellum, and spinal cord. c A number of highly edited sites in both two species were highlighted. d Two pig-biased recoding sites located in insulin-like growth factor-binding protein 7 (IGFBP7).