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. 2021 Jun 10;4:711. doi: 10.1038/s42003-021-02259-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a Congo red staining in the parenchyma was more pronounced in parietal cortical tissue from female, compared with male, AD patients and plaque area was significantly increased (*p < 0.05; n = 5; scale bar = 100 μm). b Vascular amyloid staining was significantly greater in sections prepared from male AD patients compared with females (***p < 0.001; n = 5; scale bar = 400 μm). c CD68 immunoreactivity was significantly greater in parietal cortex from male, compared with the female, AD patients (*p < 0.05, 1-tailed t-test; n = 4 except for AD females where n = 5; scale bar = 100 μm; magnified image, 50 μm). Data, expressed as means ± SEM (n = 5), were analysed by the Student’s t-test (1-tailed t-test for CD68 and 2-tailed for amyloid staining).