Table 2.

Deflection of biochemical indices in HCC patients (n = 87).

	Tandem size				P-value	Doxorubicin loading				P-value
	75 μm (n = 26)		100 μm (n = 61)			Half-loaded (n = 15)		Full-loaded (n = 72)
	Before	After	Before	After		Before	After	Before	After
AST (U/L)
Mean ± SD	61.4 ± 51.4	78.5 ± 68.2	56.4 ± 32.5	107.6 ± 135.6		42.9 ± 20.6	50.2 ± 19.2	61.0 ± 41.1	109.0 ± 129.3
Difference	17.1 ± 36.4		51.2 ± 133.2		0.547	7.3 ± 27.4		48.0 ± 123.8		0.120
ALT (U/L)
Mean ± SD	50.6 ± 50.4	67.0 ± 61.8	41.2 ± 25.8	72.1 ± 91.4		38.3 ± 21.3	45.8 ± 31.6	45.2 ± 37.2	75.8 ± 89.7
Difference	16.4 ± 29.5		30.9 ± 82.8		0.915	7.5 ± 24.9		30.6 ± 77.0		0.146
T-bil (mg/dL)
Mean ± SD	0.8 ± 0.3	1.1 ± 0.5	0.9 ± 0.6	1.3 ± 1.1		1.0 ± 0.5	1.2 ± 0.7	0.9 ± 0.6	1.3 ± 1.0
Difference	0.3 ± 0.4		0.4 ± 0.6		0.788	0.2 ± 0.4		0.4 ± 0.6		0.353
Albumin (g/dL)
Mean ± SD	3.9 ± 0.5	3.8 ± 0.6	3.8 ± 0.6	3.8 ± 0.7		3.6 ± 0.4	3.5 ± 0.5	3.9 ± 0.6	3.9 ± 0.7
Difference	− 0.1 ± 0.3		− 0.04 ± 0.6		0.187	− 0.1 ± 0.3		− 0.1 ± 0.5		0.566
PLT (103/μl)
Mean ± SD	121.5 ± 67.4	122.4 ± 65.5	148.6 ± 76.0	150.6 ± 75.7		132.6 ± 51.0	139.4 ± 70.9	142.2 ± 78.3	142.8 ± 74.6
Difference	0.9 ± 51.4		2.0 ± 60.2		0.784	6.8 ± 57.0		0.6 ± 57.9		0.567
CRE (mg/dL)
Mean ± SD	1.4 ± 1.9	1.3 ± 1.7	1.0 ± 0.6	1.0 ± 0.5		1.3 ± 0.6	1.3 ± 0.6	1.1 ± 1.2	1.0 ± 1.1
Difference	− 0.04 ± 0.2		− 0.03 ± 0.2		0.897	− 0.04 ± 0.3		− 0.04 ± 0.2		0.629

Mann–Whitney test used to compare changes of values from baseline between different TANDEM size or different doxorubicin-loading dose.

AST aspartate aminotransferase, ALT alanine aminotransferase, T-bil Total bilirubin, PLT platelet, CRE creatinine.