Table 7.
Statistics of treatment response and length of hospital stay stratified by both TANDEM size and drug-loading concentration.
| TANDEM size | P-valuea | |||||
|---|---|---|---|---|---|---|
| 75 μm | 100 μm | |||||
| Half-loaded (Group 1, n = 4) | Full-loaded (Group 2, n = 22) | Half-loaded (Group 3, n = 11) | Full-loaded (Group 4, n = 50) | |||
| Treatment response | 0.020 | |||||
| CR | 1 (25.0%) | 6 (27.3%)* | 7 (63.6%) | 9 (18.0%)‡ | ||
| PR | 0 (0.0%) | 11 (50.0%) | 3 (27.3%) | 18 (36.0%) | ||
| SD | 3 (75.0%) | 3 (13.6%) | 1 (9.1%) | 11 (22.0%) | ||
| PD | 0 (0.0%) | 2 (9.1%) | 0 (0.0%) | 12 (24.0%) | ||
| ORR | 0.016 | |||||
| Yes (CR + PR) | 1 (25.0%) | 17 (77.3%) | 10 (90.9%)* | 27 (54.0%)‡ | ||
| No (SD + PD) | 3 (75.0%) | 5 (22.7%) | 1 (9.1%) | 23 (46.0%) | ||
| DCR | 0.144 | |||||
| Yes (CR + PR + SD) | 4 (100.0%) | 20 (90.9%) | 11 (100.0%) | 38 (76.0%) | ||
| No (PD) | 0 (0.0%) | 2 (9.1%) | 0 (0.0%) | 12 (24.0%) | ||
| Length of hospital stay (days) | 2.0 ± 2.0 | 3.0 ± 1.9 | 1.6 ± 1.3 | 4.2 ± 2.3†,‡ | < 0.001 | |
Treatment response, ORR and DCR were resented as number and percentage.
Length of hospital stay were presented as mean ± SD (days).
aFisher's exact test and Kruskall-Wallis test was performed for treatment response and length of hospital stay, respectively.
*P < 0.05 compared to Group 1 by Fisher's exact test for treatment response and Mann–Whitney test for length of hospital stay.
†P < 0.05 compared to Group 2 by Fisher's exact test for treatment response and Mann–Whitney test for length of hospital stay.
‡P < 0.05 compared to Group 3 by Fisher's exact test for treatment response and Mann–Whitney test for length of hospital stay.
CR complete response, PR partial response, SD stable disease, PD progressive disease, ORR objective response rate, DCR disease control rate.