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. 2021 Jun 10;11:12312. doi: 10.1038/s41598-021-91773-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Distribution of IgG plasma levels in the different populations. (a) Distribution of IgG plasma levels in the cohort of IgG positive individuals (IgG ≥ 12 AU/mL) negative or positive for the nasopharyngeal swab or ascertained COVID-19 disease. (b) Distribution of IgG plasma levels in IgG positive individuals (IgG ≥ 12 AU/mL) divided by sex. (c) Distribution of IgG plasma levels in IgG positive individuals (IgG ≥ 12 AU/mL) divided by age ranges and sex. In (a) and (b) p-values were determined using Cochran Mantel-Haenzel test for trend. In (c) Cuzick’s test for trend was used: p = 0.0002 (total); p = 0.0085 (female); p = 0.008 (male); p = 0.4192 (interaction).