Table 2.
Rheumatological clinical and imaging features according to Whipple disease entity.
| CWD N = 11 |
LWD N = 24 |
AWD N = 15 |
PAWD N = 18 |
Total N = 68 |
|
|---|---|---|---|---|---|
| Clinical features n/N (%) | |||||
| Exclusive peripheral involvement | 6/11 (55) | 15/24 (63) | 9/15 (60) | 12/18 (67) | 42/68 (62) |
| Axial +/− peripheral involvement | 5/11 (45) | 9/24 (38) | 6/15 (40) | 6/18 (33) | 26/68 (38) |
| Arthritis | 10/11 (91) | 22/24 (92) | 13/15 (87) | 15/18 (83) | 60/68 (88) |
| Inflammatory arthralgia | 11/11 (100) | 21/24 (88) | 12/15 (80) | 18/18 (100) | 62/68 (91) |
| Monoarticular involvement | 1/7 (14) | 2/22 (9.1) | 0/10 (0) | 1/13 (7.7) | 4/52 (7.7) |
| Oligoarticular involvement | 3/7 (43) | 12/22 (55) | 3/10 (30) | 7/13 (54) | 25/52 (48) |
| Polyarticular involvement | 3/7 (43) | 8/22 (36) | 7/10 (70) | 5/13 (38) | 23/52 (44) |
| Symmetric | 3/8 (38) | 8/20 (40) | 4/8 (50) | 5/9 (56) | 20/45 (44) |
| Intermittent | 4/8 (50) | 19/21 (90) | 11/12 (92) | 8/12 (67) | 42/53 (79) |
| Inflammatory back pain | 5/11 (45) | 8/24 (33) | 5/14 (36) | 7/18 (39) | 25/67 (37) |
| Imaging features n/N (%) | |||||
| Radiographic joint space narrowing | 4/7 (57) | 4/13 (31) | 4/8 (50) | 4/13 (31) | 16/41 (39) |
| Radiographic erosions | 4/10 (40) | 4/21 (19) | 1/10 (10) | 1/15 (6.7) | 10/56 (18) |
| Radiographic destruction | 2/10 (20) | 2/19 (11) | 2/10 (20) | 0/14 (0) | 6/53 (11) |
| Spondylodiscitis on MRI | 0/0 (0) | 2/8 (25) | 1/3 (33) | 0/2 (0) | 3/13 (23) |
| Sacroiliitis on CT and/or MRI | 2/3 (67) | 1/5 (20) | 3/4 (75) | 1/3 (33) | 7/15 (47) |
AWD arthropathic Whipple disease; CT computed tomography; CWD classic Whipple disease; LWD localized Whipple disease; MRI magnetic resonance imaging; PAWD probably arthropathic Whipple disease.