Table 1.
Healthy volunteers (HV) and Primary Sjögren’s syndrome (pSS) patient characteristics.
| HV (N = 330) | pSS Discovery (N = 227) | pSS Validation (N = 77) | pSS All (N = 304) | |||
|---|---|---|---|---|---|---|
| Demography | ||||||
| Age | n | 330 | 227 | 77 | 304 | |
| Mean ± SD | 53.294 ± 10.998 | 58.524 ± 13.440 | 58.039 ± 13.554 | 58.401 ± 13.448 | ||
| Gender | n | 330 | 227 | 77 | 304 | |
| Female | n (%) | 302 (91.52) | 211 (92.95) | 71 (92.21) | 282 (92.76) | |
| Obesity (BMI > = 30) | n | 328 | 218 | 74 | 292 | |
| Yes | n (%) | 24 (7.27) | 30 (13.76) | 3 (4.05) | 33 (11.30) | |
| Race | n | 330 | 227 | 77 | 304 | |
| Asian | n (%) | 2 (0.61) | 1 (0.44) | 1 (1.30) | 2 (0.66) | |
| Black/African American | n (%) | — | — | 1 (1.30) | 1 (0.33) | |
| Caucasian/White | n (%) | 328 (99.39) | 224 (98.68) | 74 (96.10) | 298 (98.03) | |
| Other | n (%) | — | 2 (0.88) | 1 (1.30) | 3 (0.99) | |
| Diagnostic criteria | ||||||
| Focus score > 1 | n | — | 82 | 27 | 109 | |
| Yes | n (%) | — | 73 (89.02) | 24 (88.89) | 97 (88.99) | |
| Anti-SSA positivity | n | — | 227 | 77 | 304 | |
| Yes | n (%) | — | 205 (90.30) | 69 (89.61) | 274 (90.13) | |
| Disease activity | ||||||
| Disease duration, years | n | — | 225 | 77 | 302 | |
| Mean ± SD | — | 10.788 ± 7.535 | 11.094 ± 9.620 | 10.866 ± 8.101 | ||
| Disease activity (PGA*) | n | — | 211 | 75 | 286 | |
| Mean ± SD | — | 25.687 ± 18.976 | 24.840 ± 20.984 | 25.465 ± 19.488 | ||
| ESSDAI (**) | n | — | 133 | 60 | 193 | |
| Mean ± SD | — | 4.609 ± 5.358 | 4.850 ± 5.495 | 4.684 ± 5.388 | ||
| ESSPRI (**) | n | — | 106 | 44 | 150 | |
| Mean ± SD | — | 5.176 ± 2.286 | 4.568 ± 2.648 | 4.998 ± 2.405 |
n: Number of patients with available information.
(*) PGA: Physician Global Assessment.
(**) collected in a substudy.