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. 2021 Mar 31;37(6):815–830. doi: 10.1007/s12264-021-00661-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Open-loop paradigms in the AIBM system. A Schematic (left) and photograph (right) of the two-chamber paradigm. B Representative trajectories of control (left) and the restrained (right) groups collected by the infrared position detector. C Representative trajectories of the control (left) and restrained (right) groups collected by video camera. D Percentages of time spent in the food (upper) and no-food (lower) region; data collected with the infrared detector (left) and video camera (right). FR, food region; NFR, no-food region. E Schematic (left) and photograph (right) of the elevated plus maze (EPM) paradigm. F Representative trajectories from control (left) and restrained (right) groups collected by the infrared detector. G Representative trajectories from control (left) and restrained (right) groups collected on a video camera. H Behavioral parameters in the EPM paradigm. Percentages of time spent in, and the number entries into, the closed/open arm. Data were collected with the infrared position detector (left) and video camera (right). Res, restrained. n = 5 mice in each group. #P <0.1, *P <0.05, **P <0.01, ***P <0.001, experimental vs control groups, rank sum tests.