FIGURE 3.

Histopathological changes in CVA2-infected mice. In the brain tissue and spinal cord, neurophagy and lymphocyte infiltration occurred. The lungs presented inflammatory hyperemia characterized with massive erythrocytes leakage. The skeletal muscles exhibited myofiberlysis, necrosis, and inflammatory cell infiltration. Severe viral myocarditis was observed, characterized with lymphocytic and mononuclear cell infiltration and myocardial rupture. In control mice, the upper organs or tissues were almost unaffected. All experiments were repeated for four times.