Figure 5.

Cold acclimation results in nociceptive sensitization

(A) Representative traces of extracellular CIII recordings in control larvae.

(B) Representative traces of extracellular CIII recordings in cold acclimated larvae. Neural activity was assessed at room temperature, and during/following ramps to 20, 15, and 10°C.

(C) Average spike frequency of CIII neurons by temperature. CIII neurons in cold acclimated larvae were more sensitive to temperature drops to 20 and 15°C. Neural activity was assessed at room temperature, and during/following ramps to 20, 15, and 10°C. Differences were assessed by frequentist and Bayesian ANOVA. Bar chart details mean spike rate ±standard error of the mean. N = 43; control, n = 32; cold acclimated, n = 11. N and n refer to the number of neurons recorded from.