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. 2021 Jun 10;4:715. doi: 10.1038/s42003-021-02265-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Schematic of SARS-CoV-2 genome organisation with the whole genome depicted at the top, Nsp1 coding sequence in the middle, and a sequence alignment of Nsp1 C-terminal domain of SARS-CoV-2, SARS-CoV-1, and MERS-CoV in the lower part of the panel. The two alpha helices and the KH motif are marked by bars and an arrow, respectively. Colour coding of amino acids corresponds to default settings of the ClustalX alignment tool. b Cartoon depicting the interaction between Nsp1 and the 40S ribosomal subunit, as revealed by the structural data. The C-terminal helices anchor Nsp1 in the mRNA entry channel, thereby blocking access for host transcripts (schematically represented in grey). The globular N-terminus is not sufficiently resolved in the structures to be able to assign a clear position and function.