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. 2021 Jun 10;12(6):601. doi: 10.1038/s41419-021-03847-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Serum lipase (A) and amylase activity (B) were determined in serum collected after 12 h of treatment with saline or caerulein (n = 5−6 in each group). The results of qPCR analysis of mRNA expression in pancreatic tissue are shown in C, D. Pancreatic digestive enzyme genes (Amy2, Pnlip, Ctrc, Cela1, and Ins), genes associated with pancreatic development (Nes and Pdx1), and ductal and epithelial cell-associated genes (Cdh1, Ctnnb1, Krt7, and Krt19) were examined (n = 6 in each group). The data are presented as the means ± SEMs. *P < 0.05, **P < 0.01, and ***P < 0.001 compared to the control group. These data are representative of three experiments.