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. 2021 Jun 10;12:3537. doi: 10.1038/s41467-021-23822-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Children with ASD showed four states and TD children showed two states. Color codes distinct states in each participant. States 1, 2, 3, and 4 in children with ASD are represented by dark orange, dark cyan, dark green, and dark magenta, respectively; states 1 and 2 in TD children are represented by lime green and dark blue, respectively. b Cognitive NII (CNII) of dynamic brain states showed intermittently reduced cross-network interaction in children with ASD compared to TD children. c The temporal mean of dynamic cross-network interaction in the cognitive control circuit, assessed using mean of dynamic CNIIs across states, was significantly lower in children with ASD, compared to TD children. The temporal variability of dynamic cross-network interaction in the cognitive control circuit, assessed using standard deviation of dynamic CNIIs across states, was significantly higher in children with ASD, compared to TD children. Two-sided two sample t-tests were used to compare mean and temporal variability of CNIIs between children with ASD and TD children. Error bar shows standard error of mean. ***p < 0.001.