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. 2021 Jun 10;11:12240. doi: 10.1038/s41598-021-91444-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Carrageenan-treated mice exhibited increased mechanical and thermal sensitivities. The paw withdrawal threshold to mechanical stimuli (A) and paw withdrawal latency to thermal stimuli (B). Data are presented as mean ± SEM for n = 6/group. ***p < 0.001 compared to the vehicle-treated group and ^#p < 0.05, ^##p < 0.01 and ^###p < 0.001 compared to the carrageenan-induced group.