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. 2021 Jun 10;11:12240. doi: 10.1038/s41598-021-91444-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Long-term locomotor activity of control-, carrageenan-, carrageenan + indomethacin-treated mice in automated home-cage LABORAS. Long-term locomotor activity is demonstrated in four sections: 0–2 h (exploratory behaviors), 2–6 h (therapeutically effective duration of indomethacin at nighttime), 6–12 h, and 12–24 h (therapeutically ineffective duration of indomethacin at nighttime). The symbol of the moon indicates the nighttime and the sun for the daytime. Data are expressed as means ± SEM from 8 mice in each group. *, **, *** denote significant difference compared to the control group at p < 0.05, p < 0.01, p < 0.001, respectively. ^# and ^### denote significant difference compared to indomethacin-treated group at p < 0.05, p < 0.001, respectively.